Raquel Paes da Rocha
From DNA Repair Lab
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| == Resumo do Projeto == | == Resumo do Projeto == | ||
| - | ''C. crescentus'' é um modelo no que se refere a estudos de ciclo celular em procariontes. Pouco se sabe, no entanto, a respeito de seus mecanismos de reparo de DNA. Em seu genoma já seqüenciado, vários genes foram anotados com funções relacionadas à integridade do material genético, mas poucas análises funcionais foram realizadas. Nosso objetivo é, portanto, trazer mais informações a respeito dos mecanismos de reparo de DNA nesse organismo. Buscamos também a análise das implicações de prejuízos ao DNA para o ciclo celular singular dessa proteobactéria. | + | ''C. crescentus'' is a model organism for cell cycle studies in prokaryotes. Its DNA repair mechanisms are, however, less studied and understood. ''C. crescentus'' genome has already been sequenced and several genes have been annotated as putative members of the genetic material integrity maintenance system. Even though, only few functional studies have been done. Therefore our objective is to bring more information about the DNA repair mechanisms in this organism. We also objective to analyze the implications of DNA damage to the singular cell cycle of this proteobacteria. |
| ==Publicações== | ==Publicações== | ||
| Galhardo, RS, Rocha, R. Marques, MV and Menck, CF (2005) A SOS-regulated operon involved in damage-inducible mutagenesis in ''Caulobacter crescentus''. Nucleic Acids Research, 33 (8): 2603-2614. | Galhardo, RS, Rocha, R. Marques, MV and Menck, CF (2005) A SOS-regulated operon involved in damage-inducible mutagenesis in ''Caulobacter crescentus''. Nucleic Acids Research, 33 (8): 2603-2614. | ||
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