Research Project
Development of chemotherapy resistance is the principal cause of death for the most patients with cancer. Many factors associated with drug resistance by tumor cells have already been identified in vitro. However, the cellular responses to chemotherapy in a context closer to the tissue microenvironment still not completed understood.
Recently, increasing evidences have supported the important role of the extracellular matrix (ECM) and the three-dimensional microenvironment in tumor genesis and progression. Thus, interactions between tumor cells and their microenvironment play an essential role in regulating cell behavior. Thus, this project aims to study the role of the microenvironment influence on human breast carcinoma cells response to treatment with doxorubicin, through the use of cell cultures in three dimensions (3D).
Publications
GOMES LR, Terra LF, Sogayar MC, Labriola L. Epithelial-Mesenchymal Transition: Implications in Cancer Progression and Metastasis. Current Pharmaceutical Biotechnology, 2011.
Buchanan C, Stigliano I, Garay-Malpartido HM, RODRIGUES GOMES L, Puricelli L, Soagayar Mc, Bal de Kier Joffé E, Petters MG. Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways. Breast Cancer Research and Treatment, v. 119, p. 559-574, 2010.
Figueira RCS, GOMES LR, Neto JS, Silva FC, Silva ID, Sogayar MC. Correlation between MMPs and their inhibitors in breast cancer tumor tissue specimens and in cell lines with different metastatic potential. BMC Cancer, v. 14, p. 20, 2009.
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