Luciana Rodrigues Gomes
From DNA Repair Lab
| BS in Chemistry and PhD in Biochemistry from the University of São Paulo (USP), with a period of PhD at the Lawrence Berkeley National Laboratory (California, USA). She is currently a post-doc in the DNA repair Laboratory, where develops project related to "Role of the cellular microenvironment in the molecular mechanisms of resistance to chemotherapeutic agents in a model of breast cancer model." |
|
[edit] Research Project[edit] Role of the cellular microenvironment in the molecular mechanisms of resistance to chemotherapeutic agents in a model of breast cancer model.Development of chemotherapy resistance is the principal cause of death for the most patients with cancer. Many factors associated with drug resistance by tumor cells have already been identified in vitro. However, the cellular responses to chemotherapy in a context closer to the tissue microenvironment still not completed understood. Recently, increasing evidences have supported the important role of the extracellular matrix (ECM) and the three-dimensional microenvironment in tumor genesis and progression. Thus, interactions between tumor cells and their microenvironment play an essential role in regulating cell behavior. Thus, this project aims to study the role of the microenvironment influence on human breast carcinoma cells response to treatment with doxorubicin, through the use of cell cultures in three dimensions (3D). [edit] PublicationsGOMES LR, Terra LF, Sogayar MC, Labriola L. Epithelial-Mesenchymal Transition: Implications in Cancer Progression and Metastasis. Current Pharmaceutical Biotechnology, 2011.
|
|