Research Area: Cardiovascular
Physiology.
The aim of our research is
to study vascular mechanisms involved in pathological processes
such as hypertension, heart failure and diabetes mellitus, and
in the physiological process of ageing.
Specifically, we are
investigating:
1. Modifications in the
activity and expression of Na+K+ATPase in vascular beds with
respect to the role of endothelial modulation of the activity
and expression of this enzyme;
2. Differences in the
function of conductance and resistance vessels;
3. Modifications in the
function and expression of nitric oxide synthase isoforms and
the interaction of this pathway with free radicals;
4. Hemodynamic regulation of
vascular reactivity and of the endothelial function in
hypertensive rats treated chronically with ouabain (Na+K+ATPase
inhibitor);
5. Adaptations in vascular
reactivity after long term stimulation of adrenergic receptors;
6. The mediators of the
vascular inflammatory response involved in endothelial
dysfunction;
7. The time course of
changes in vascular functions seen in models for hypertension
and heart failure, and;
8. The intracellular
mechanisms involved in the adaptation of vascular function. |