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Molecular Biology and Vaccine Development in Plasmodium

Publications

BIBLIOGRAPHY

01. del Portillo HA, Fernandez-Becerra C, Bowman S, Oliver K, Preuss M, Sanchez, C., Schneider N, Villalobos JM, Rajandream M-A, Harris D, L. Pereira da Silva, Barrel B & Lanzer M. 2001. A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax. Nature, 410: 839-842.

02. Takashi Nomura, Jane M-R. Carlton, J. Kevin Baird, Hernando A. Del Portillo, David J. Fryauff, Dharmendar Rathore, David A. Fidock, Xin-zhuan Su, William E. Collins, Thomas F. McCutchan, John C. Wootton and Thomas E. Wellems. 2001. Evidence for different mechanisms of chloroquine resistance in two Plasmodium species that cause human malaria. J. Inf. Dis., 183: 1653 - 1661.

03. Sperança, MA, Vinkenoog R, Ocampos M, Fischer K, Janse CJ, Waters AP and del Portillo HA. 2001. Overexpression of the Plasmodium vivax crk2 gene and novel malarial/yeast cdc2-chimeras induce mitotic catastrophe. Exp. Parasitol., 97: 119-128.

04. Wunderlich G, Moura IC and del Portillo HA. 2000. Genetic Immunization of Balb/C mice with a plasmid coding for a hybrid Merozoite Surface Protein 1/Hepatitis B surface-fusion protein partially protects mice against lethal P. chabaudi chabaudi PC1 Infection. Inf. Imm., 68, 5839-5845.

05. Wunderlich, G. and del Portillo, H.A. 2000. Biochemical and immunological properties of a hybrid viral particle expressing the C-terminal region of the merozoite surface protein of Plasmodium vivax. Mol. Med. 6, 238-245.

06. Kirchgatter, K., Mosbach, R. and del Portillo, H.A. 2000. Plasmodium falciparum: DBL-1 var sequence analysis in field isolates from Central Brazil. Exp. Parasitol., Exp. Parasitol., 95, 154-157.

07. Oliveira, CI., Wunderlich, G., Levitus, GL., Soares IS., Rodrigues MM., Tsuji, M., and del Portillo, H.A. 1999. Antigenic properties of the Merozoite Surface Protein 1 gene of Plasmodium vivax. Vaccine, 17: 2959-2968.

08. Soares IS, Da Cunha MG, Silva MN, Souza JM, del Portillo H.A, and Rodrigues MM. 1999. Longevity of naturally acquired antibody responses to the N- and C-terminal regions of Plasmodium vivax Merozoite Surface Protein1. Am. J. Trop. Med. Hyg., 60: 357-363.

09. Kirchgatter, K., and del Portillo, H.A. 1998. Molecular analysis of Plasmodium vivax relapses using the MSP1 molecule as a genetic marker. J. Inf. Dis. 177: 511-515.

10. Vinkenoog, R., Aparecida, MS., van Breemen, O., Ramesar, J., Williamson, D.H., Ross-MacDonald, PB., Thomas, AW., Janse, CJ., del Portillo, H.A., and Waters, AP. 1998. Malaria parasites contain two identical copies of an elongation factor 1 alpha gene. Mol. Biochem. Parasitol. 94: 1-12.

11. Vinkenoog, R., Aparecida, MS., Ramesar, J., Thomas. AW., del Portillo, H.A., Janse, CJ., and Waters, AP. 1998. Characterization of the Cdc2-related kinase 2 gene from Plasmodium knowlesi and P. berghei. Mol. Biochem. Parasitol. 95: 229-240.

12. Camargo, AA., Fisher, K., Lanzer, M. and del Portillo, H.A. 1997. Construction of a genomic library of Plasmodium vivax in Yeast Artificial Chromosomes. Genomics, .42: 467-473.

13. Soares I, Levitus G, del Portillo H.A and Rodrigues MM. 1997. Characterization of naturally acquired cellular and human immune reponses against the MSP1 protein of Plasmodium vivax. Infection and Immunity, 65: 1606 - 1614.

14. Levitus, G., Mertens, F., Kirchgatter, K, Oliveira, SG and del Portillo, H.A. 1997. Plasmodium vivax: epitope mapping of Mabs against the N-terminal region of the MSP1 molecule. Behring Institute Res. Comm. 99:107-111.

15. Moreira, M.E.C., del Portillo, H.A., Balanco, M., Milder, R.V. and Barcinski, M. 1996. Heat shock induction of apoptosis in a unicellular organism. J. Cell. Physiol., 167: 305-313.

16. Waters, A.P., Wirth, D.F., Wellems, T.E. and del Portillo, H.A. 1996. Transfection of Malaria. Parasitology Today, 12: 129-132.

17. Vinkenoog, R., Veldhuisen, B., Sperança, M.A., del Portillo, H.A., Janse, C. and Waters, A. 1995. Comparison of introns in a cdc2-homologous gene within a number of Plasmodium species. Mol. Biochem. Parasitol., 71: 233-241.

18. Levitus, G. and del Portillo, H.A. 1994. Advances toward the development of an asexual blood-stage MSP-1 vaccine of Plasmodium vivax. Mem. Inst. Oswaldo Cruz (Special Issue on the Proceedings of the CEC/Latin American Malaria Conference), 89 (II): 81-84.

19. Janse, C., Camargo, A.A., del Portillo, H.A., Herrera, S., Kumlien, S., Mons, B. and Water, A.P. 1994. Removal of leukocytes from Plasmodium vivax-infected blood. Annals of Tropical Medicine and Parasitology, 88(2): 213-216.

20. Mancilla, L.I., Levitus, G., Kirchgatter, K., Mertens, F., Herrera, S. and del Portillo H.A. 1994. Plasmodium vivax: Dimorphic DNA sequences from the MSP-1 gene codes for regions that are immunogenic in natural infections. Exp. Parasitol., 79: 148-158.

21. Levitus, G., Mertens, F., Sperança, M.A., Camargo, L.M.A., Ferreira, M.U. and del Portillo, H.A. 1994. Characterization of the naturally acquired IgG immune responses against the Merozoite Surface Protein 1 of Plasmodium vivax. Am. J. Trop. Med. Hyg., 51(1): 68-76.

22. Mertens, F., Levitus, G., Ferreira, M.U., Camargo, L.M.A., Dutra, A.P. and del Portillo, H.A. 1993. Longitudinal study of naturally acquired humoral immune responses against the Merozoite Surface protein 1 of in patients from Rondônia, Brazil. Am. J. Trop. Med. Hyg. 49: 383-392.

23. del Portillo, H.A., Barreiro, L., Camargo, A.A. and Levitt, A. 1993. Amplification of single copy genes of Plasmodium vivax from two drops of peripheral blood of infected patients. J. Protozool. Res. 3: 20-24.

24. del Portillo, H.A., Levitus, G., Camargo, L.M.A., Ferreira, M.U. and Mertens, F. 1992. Human IgG reponses against the N-terminal region of the merozoite surface protein 1 of Plasmodium vivax. Mem. Inst. Oswaldo Cruz (Special issue on the Proccedings of the IV International Congress on Malaria and Babesiosis) 87(3): 77-84.

25. Porto, M., Ferreira, M.U., Camargo, L.M.A. and del Portillo, H.A. 1992. A new allele of the Merozite surface protein 1 gene of Plasmodium vivax. Mol. Biochem. Parasitol. 54: 121-124.

26. del Portillo, H.A., Longacre, S., Khouri, E. and David, P.H. 1991. Primary structure of the merozoite surface antigen 1 of Plasmodium vivax reveals sequences conserved between different Plasmodium species. Proc. Natl. Acad. Sci. USA. 88: 4030-4034.

27. del Portillo, H.A., Certa, U., Langsley, G. and Herrera, S. 1989. Basic techniques for the molecular biology of Plasmodia: a laboratory manual. Ediciones UniValle.

28. del Portillo, H.A., Gysin, J., Mattei, D.M., Khouri, E., Udagama, P.V., Mendis, K.N. and David, P.H. 1988. Plasmodium vivax: cloning and expression of a major blood-stage surface antigen. Exp. Parasitol. 63: 346-353.

29. David, P.H., del Portillo, H.A. and Mendis, K.N. 1988. Plasmodium vivax: parasite biology defines potential targets for vaccine development. Biol. Cell. 64: 251-260.

30. del Portillo, H.A. 1988. Perspectivas para una nueva vacuna sintética contra la malaria. Interciencia 13: 262-263.

31. del Portillo, H.A., Nussenzwieg, R.S. and Enea, V. 1987. Circumsporozoite gene of a Plasmodium falciparum strain from Thailand. Mol. Biochem. Parasitol. 24: 289-294.

32. Yoshida, N., del Portillo, H.A., di Santi, S.M., Nussenzweig, R.S. and Enea, V. 1987. Plasmodium falciparum: epidemiological studies on the circumsporozoite gene. Exp. Parasitol. 64: 510-513.

33. del Portillo, H.A., Schmidt, G.W. and Damian, R.T. 1987. Immunochemical analysis of baboon (Papio cynocephalus) IgG subclasses. Vet. Immunol. Immunopathol. 16: 201-214.

34. del Portillo, H.A. and Damian, R.T. 1986. Experimental Schistosoma mansoni infection in a small New World monkey, the saddle-back tamarin (Saguinus fuscicollis). Am. J. Trop. Med. Hyg. 35: 515-522.

35. del Portillo, H.A. and Dimock, R.V. 1982. Specificity of the host-induced negative phototaxis of the symbiotic water-mite Unionicola formosa. Biol. Bull. 162: 163-170.
36. del Portillo, H.A., Cufino, F. and Ramirez, J.M. 1980. Aotus trivirgatus del Catatumbo-Colombia (cariotipo). Revista de la Universidad de La Salle 2: 49-55.