Danilo Batista Vieira de Melo

From Laboratório de Reparo de DNA

Revisão de 18:00, 27 Abril 2018; ver versão actual
← Versão anterior | Versão posterior →
Graduando em Ciências Biológicas pela Universidade de São Paulo IB-USP
É bolsista de Iniciação Científica orientado pelo Prof Dr. Carlos Frederico Martins Menck e co-orientado pela Dra. Ligia Pereira Castro.

Research keywords: DNA Repair, Photolesions,Aging and Inflammation.

Lattes

Contato: gustkajitani[at]gmail.com



Current Project

Effects of DNA lesions on Nucleotide Excision Repair deficient mice

The Nucleotide Excision Repair (NER) pathway is responsible for the removal and repair of bulky DNA lesions capable of distorting the structure of the DNA double helix, such as cisplatin or UV induced lesions. Defects in genes related to the Nucleotide Excision Repair (NER) pathway lead to disorders in which patients display photosensitivity and/or neurological problems, such as Xeroderma Pigmentosum (XP), Cockayne Syndrome (CS). In order to study the impact of DNA damage in these genetic diseases, numerous knockout mice models have been developed, with several of them having similar characteristics to the human syndromes. In this project, we aim to study the impact of specific UV induced lesions (CPDs or 6-4PPs) on the induction of effects such as skin hyperplasia, cell death and inflammation on a XP mouse model. Moreover, we have used a Cockayne Syndrome mouse model in order to study the relationship between the molecular defects of CS and possible neuropathological phenotypes, namely vascular dysfunction and neuroinflammation.

Publications

Rocha, C.R.R., Kajitani, G.S., Quinet, A., Fortunato, R.S. and Menck, C.F.M., 2016. NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells. Oncotarget, 7(30), p.48081.
Full Text

de Oliveira Alves, N., Vessoni, A.T., Quinet, A., Fortunato, R.S., Kajitani, G.S., Peixoto, M.S., de Souza Hacon, S., Artaxo, P., Saldiva, P., Menck, C.F.M. and de Medeiros, S.R.B., 2017. Biomass burning in the Amazon region causes DNA damage and cell death in human lung cells. Scientific reports, 7(1), p.10937.
Full Text

Ferramentas pessoais