Carlos Frederico Martins Menck

From Laboratório de Reparo de DNA

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Revisão de 17:15, 1 Setembro 2011
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==Principais Publicações== ==Principais Publicações==
-09. Lima-Bessa K, Chiganças V, Stary A, Kanouche P, Sarasin A, Armelini MG, Jacysyn JF, Amarantes-Mendes GP, Cordeiro-Stone M, Cleaver JE and Menck CFM (2006). Adenovirus mediated transduction of the human DNA polymerase eta cDNA. DNA Repair 5: 925-934.+01. Menck, CFM (2002) [http://www.nature.com/ng/journal/v32/n3/full/ng1102-338.html Shining a light on photolyases. Nature Genetics, News and Views, 32: 338-339.]([http://www.nature.com/ng/journal/v32/n3/pdf/ng1102-338.pdf PDF])
-08. Batista LFZ, Chiganças V, Brumatti G, Amarante-Mendes GP and Menck CFM (2006) Involvement of DNA replication in ultraviolet-induced apoptosis of mammalian cells. Apoptosis 11(7): 1139-1148.+02. Costa RM, Chiganças V, Galhardo RS, Carvalho H, Menck CFM (2003) [http://www.sciencedirect.com/science/article/pii/S0300908403001950 The eukaryotic nucleotide excision repair pathway. Biochimie, 85: 1083-1099.]([http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VRJ-4B5503G-2-9&_cdi=6236&_user=5674931&_pii=S0300908403001950&_origin=&_coverDate=11%2F30%2F2003&_sk=999149988&view=c&wchp=dGLbVzW-zSkWz&md5=9b6b53c0809f91cde57da87249e21d36&ie=/sdarticle.pdf PDF])
-07. Galhardo, RS, Rocha, R. Marques, MV and Menck, CF (2005) A SOS-regulated operon involved in damage-inducible mutagenesis in Caulobacter crescentus. Nucleic Acids Research 33 (8): 2603-2614.+03. Marchetto MCN*, Muotri AR*, Burns DK, Friedberg EC and Menck CFM (2004) [http://www.pnas.org/content/101/51/17759.full Gene transduction in skin cells: preventing cancer in xeroderma pigmentosum mice. Proc. Natl. Acad. Sci. USA 101 (51): 17759-64. Both authors have equally contributed.]([http://www.pnas.org/content/101/51/17759.full.pdf+html PDF])
-06. Armelini MG, Muotri AR, Marchetto MCN, Lima-Bessa KM, Sarasin A and Menck CFM (2005) Restoring DNA repair capacity of cells from three distinct diseases by XPD gene recombinant adenovirus. Cancer Gene Therapy 12(4): 389-396.+04. Lima-Bessa KM, Armelini MG, Chiganças V, Jacysyn JF, Amarantes-Mendes GP, Sarasin A and Menck CFM (2008) [http://www.sciencedirect.com/science/article/pii/S1568786407003801 CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells, DNA Repair 7(2): 303-312.]([http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6X17-4RDB91D-1-F&_cdi=7235&_user=5674931&_pii=S1568786407003801&_origin=&_coverDate=02%2F01%2F2008&_sk=999929997&view=c&wchp=dGLbVlW-zSkzk&md5=9272ebe8d2d64fc1be9e9d0ca3ad97a7&ie=/sdarticle.pdf PDF])
-05. Lima-Bessa, KM and Menck, CFM (2005) Skin cancer: lights on genome lesions. Current Biology, 15(2): R58-R61.+05. Batista LF, Kaina B, Meneghini R, Menck CF (2009) [http://www.sciencedirect.com/science/article/pii/S1383574208001361 How DNA lesions are turned into powerful killing structures: Insights from UV-induced apoptosis. Mutat Res Reviews, 681(2-3):197-208.]([http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T2G-4TGHNJX-2-7&_cdi=4918&_user=5674931&_pii=S1383574208001361&_origin=&_coverDate=06%2F30%2F2009&_sk=993189997&view=c&wchp=dGLzVzb-zSkzV&md5=8199043bcbbd880bb707f209988c93ca&ie=/sdarticle.pdf PDF])
-04. Marchetto MCN*, Muotri AR*, Burns DK, Friedberg EC and Menck CFM (2004) Gene transduction in skin cells: preventing cancer in xeroderma pigmentosum mice. Proc. Natl. Acad. Sci. USA 101 (51): 17759-64. Both authors have equally contributed.+06. Lima WC, Varani AM and Menck CF (2009) [http://mbe.oxfordjournals.org/content/26/2/399.full NAD biosynthesis evolution in bacteria: lateral gene transfer of kynurenine pathway in Xanthomonadales and Flavobacteriales. Molecular Biology of Evolution, 26(2): 399-406.]([http://mbe.oxfordjournals.org/content/26/2/399.full.pdf+html PDF])
-03. Chiganças V, Sarasin, A and Menck, CF (2004) CPD-photolyase adenovirus-mediated gene transfer in normal and DNA repair deficient human cells. Journal Cell Science 117: 3579-3592.+07. Leite, RA, Marchetto, MC, Muotri, AC, Vasconcelos, DM, Oliveira, ZNP, Machado MCR , Menck, CF (2009) [http://www.nature.com/jid/journal/v129/n2/full/jid2008239a.html Identification of XP complementation groups by recombinant adenovirus carrying DNA repair genes. Journal Investigative Dermatology, 129(2):502-506.]([http://www.nature.com/jid/journal/v129/n2/pdf/jid2008239a.pdf PDF])
-02. Costa RM, Chiganças V, Galhardo RS, Carvalho H, Menck CFM (2003) The eukaryotic nucleotide excision repair pathway. Biochimie, 85: 1083-1099.+08. Batista LF, Roos WP, Kaina B and Menck CF (2009) [http://mcr.aacrjournals.org/content/7/2/237.full p53 mutant human glioma cells are sensitive to UV-C induced apoptosis due to impaired CPD removal. Molecular Cancer Research 7(2): 237-246.]([http://mcr.aacrjournals.org/content/7/2/237.full.pdf+html PDF])
-01. Menck, CFM (2002) Shining a light on photolyases. Nature Genetics, News and Views, 32: 338-339.+09. Cutiño-Jiménez AM, Martins-Pinheiro M, Lima WC, Martín-Tornet A, Morales OG, Menck CFM (2010) [http://www.sciencedirect.com/science/article/pii/S1055790309003832 Evolutionary placement of Xanthomonadales based in conserved protein signature sequences. Molecular Phylogenetics and Evolution, 54: 524-534.]([http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WNH-4X9TTVC-2-V&_cdi=6963&_user=5674931&_pii=S1055790309003832&_origin=&_coverDate=02%2F28%2F2010&_sk=999459997&view=c&wchp=dGLzVzz-zSkWz&md5=2a786750a6dbe2a249ee337bd62463a4&ie=/sdarticle.pdf PDF])
-|}+ 
 +10. Schuch AP, Menck CF (2010) [http://www.sciencedirect.com/science/article/pii/S1011134410000679 The genotoxic effects of DNA lesions induced by artificial UV-radiation and sunlight. J Photochem Photobiol B; 99(3): 111-116.]([http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TH0-4YMPX7D-1-C&_cdi=5268&_user=5674931&_pii=S1011134410000679&_origin=&_coverDate=06%2F01%2F2010&_sk=999009996&view=c&wchp=dGLbVlW-zSkzS&md5=a65c5655b5b8d94d116fc41da8c0c325&ie=/sdarticle.pdf PDF])

Revisão de 17:15, 1 Setembro 2011

Professor Titular do Depto. de Microbiologia, do Instituto de Ciências Biomédicas, Universidade de São Paulo. Graduado em Biologia e Doutorado em Bioquímica.

Projeto de Pesquisa

Seus principais interesse em pesquisa consistem nos estudos de processos celulares de reparo de DNA e suas consequencias biológicas (tais como mutagênese e morte celular). Em conjunto com seu grupo tem desenvolvido sistemas relacionados a terapia gênica, sendo que também propõe o uso de RNAi como importante ferramenta para entender as respostas celulares a agressões no genoma, em células animais. Considerando a grande conservação dos genes de reparo de DNA nos diferentes seres vivos, também estuda como esses processos ocorrem em plantas e mesmo em bactérias (tendo Caulobacter crescentus como modelo). Esses estudos permitem uma abordagem evolutiva ao tema. Pesquisa.

Principais Publicações

01. Menck, CFM (2002) Shining a light on photolyases. Nature Genetics, News and Views, 32: 338-339.(PDF)

02. Costa RM, Chiganças V, Galhardo RS, Carvalho H, Menck CFM (2003) The eukaryotic nucleotide excision repair pathway. Biochimie, 85: 1083-1099.(PDF)

03. Marchetto MCN*, Muotri AR*, Burns DK, Friedberg EC and Menck CFM (2004) Gene transduction in skin cells: preventing cancer in xeroderma pigmentosum mice. Proc. Natl. Acad. Sci. USA 101 (51): 17759-64. Both authors have equally contributed.(PDF)

04. Lima-Bessa KM, Armelini MG, Chiganças V, Jacysyn JF, Amarantes-Mendes GP, Sarasin A and Menck CFM (2008) CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells, DNA Repair 7(2): 303-312.(PDF)

05. Batista LF, Kaina B, Meneghini R, Menck CF (2009) How DNA lesions are turned into powerful killing structures: Insights from UV-induced apoptosis. Mutat Res Reviews, 681(2-3):197-208.(PDF)

06. Lima WC, Varani AM and Menck CF (2009) NAD biosynthesis evolution in bacteria: lateral gene transfer of kynurenine pathway in Xanthomonadales and Flavobacteriales. Molecular Biology of Evolution, 26(2): 399-406.(PDF)

07. Leite, RA, Marchetto, MC, Muotri, AC, Vasconcelos, DM, Oliveira, ZNP, Machado MCR , Menck, CF (2009) Identification of XP complementation groups by recombinant adenovirus carrying DNA repair genes. Journal Investigative Dermatology, 129(2):502-506.(PDF)

08. Batista LF, Roos WP, Kaina B and Menck CF (2009) p53 mutant human glioma cells are sensitive to UV-C induced apoptosis due to impaired CPD removal. Molecular Cancer Research 7(2): 237-246.(PDF)

09. Cutiño-Jiménez AM, Martins-Pinheiro M, Lima WC, Martín-Tornet A, Morales OG, Menck CFM (2010) Evolutionary placement of Xanthomonadales based in conserved protein signature sequences. Molecular Phylogenetics and Evolution, 54: 524-534.(PDF)

10. Schuch AP, Menck CF (2010) The genotoxic effects of DNA lesions induced by artificial UV-radiation and sunlight. J Photochem Photobiol B; 99(3): 111-116.(PDF)

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