Natalia Cestari Moreno

From Laboratório de Reparo de DNA

BSc, Biological Sciences, Universidade Estadual do Norte do Paraná (UENP) (2004-2008).
MSc, Genetics and Molecular Biology, Universidade Estadual de Londrina (UEL) (2009-2011).
PhD, Biology, Genetics, Universidade de São Paulo (USP) (2013-2017).

The researcher has experience in cell biology, molecular biology, new generation sequencing, culture of human cells, drug testing, redox process, cytotoxicity, genotoxicity and mutagenesis assessment. In addition, have experience in research related to Ultraviolet light-induced deleterious effects, especially UVA light, on Xeroderma Pigmentosum human cells.

Post-doctoral researcher in the DNA Repair Lab - Institute of Biological Sciences at University of São Paulo (Current).

Research keywords: UVA light, Xeroderma Pigmentosum Variant, cytotoxicity, redox process, DNA repair, translesion synthesis, DNA damage response, mutagenesis, skin cancer.

Contato: ncmoreno[at]


Current Project

Contribution of UVA-induced damage to deleterious effects and cells transformation from Xeroderma Pigmentosum patients

UVA light (UVA) is an environmental agent that induces DNA and proteins damage, which are related to consequences such as skin aging and carcinogenesis. The UVA light induces mainly pyrimidine cyclobutane (CPDs) and oxidized bases (for example, 8-oxoG). The important functions of nucleotide excision repair (NER) and translesion synthesis (TLS) to protect people against skin cancer is evident because of a rare hereditary disease, known as Xeroderma Pigmentosum (XP), where patients carry mutations in the genes of these pathways. Concomitant with the induction of DNA damage, protein oxidation has been shown to be a factor accounting for the carcinogenic phenotype, previously neglected, as it can target NER proteins and compromise their functions. The project aims to elucidate the participation of CPDs and oxidative stress in the deleterious effects of UVA light on XP variant (XP-V) patient cells, to understand the mechanism by which NER is attenuated after exposure to UVA and the contribution of UVA light-induced DNA damages in the skin carcinogenesis of normal and XP people, with emphasis on redox processes.


2014 - Honorable mention for the participation of the Post-Graduation Panel Award with the work in the area of mutagenesis, titled “UVA induced DNA damage responses in Xeroderma Pigmentosum patients cells”, presented during the 60th Brazilian Congress of Genetics, from August 26 to 29, 2014, in Guarujá, SP, Brazil.
2016 - Selected for oral presentation at the XII Congress of Mutagen-Brazil, with the work titled: “UVA light induces DNA damage and mutagenesis in normal cells and Xeroderma pigmentosum variant patient cells”, in the period from January 28 to 30, 2016, in Indaiatuba, SP, Brazil.


MORENO, NATÁLIA CESTARI; SOFIA, SILVIA HELENA; MARTINEZ, CLAUDIA B.R. Genotoxic effects of the herbicide Roundup Transorb® and its active ingredient glyphosate on the fish Precious lineouts. Environmental Toxicology and Pharmacology., v. 37, p.448-454, 2014.
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SCHUCH, A. P.; MORENO, N. C.; SCHUCH, N. J.; MENCK, C. F. M.; GARCIA, C. C. M. Sunlight damage to cellular DNA: Focus on oxidatively generated lesions. Free Radical Biology and Medicine, v. 107, p. 110-124, 2017.
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YAGURA, T.; SCHUCH, A. P.; GARCIA, C. C. M.; ROCHA, C. R. R.; MORENO, N. C.; ANGELI, J. P. F.; MENDES, D.; SEVERINO, D.; SANCHEZ, A. B.; MASCIO, P.; MEDEIROS, M. H. G.; MENCK, C. F. M. Direct participation of DNA in the formation of singlet oxygen and base damage under UVA irradiation. Free Radical Biology and Medicine, v. 108, p. 86–93, 2017.
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