Teiti Yagura

From DNA Repair Lab

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I'm an undergraduate student of the course called "Basic Sciences for Health", first course of the Institute of Biomedical Sciences of the University of São Paulo, and I develop a project entitled "Determination of the Mecanisms of Lesion Induction at the DNA Molecule by Irradiation with UVA", under the orientation of Professor Doctor Carlos Frederico Martins Menck and the co-orientation of André Passaglia Schuch.

Research Project

The purpose of my work is the irradiation of DNA samples with UVA light in the presence of different substances to study the possible mechanisms involved in the induction of DNA lesions by these wavelengths. The determination and quantification of different types of DNA lesions formed after irradiation will be performed using enzymes for DNA repair (glycosylase and endonucleases) that recognize and cleave the site containing specific lesions. Complementing these analyses, immunological and chromatographic tests will be conducted. With the implementation of these analyses we seek to uncover how the damages induced by UVA light in the DNA molecule are generated by examining the indirect (reactive species) and direct (photon absorption by the DNA molecule) mechanisms.

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