Stephano Spanó Mello

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Graduated in Biological Sciences in Universidade de São Paulo (USP), Master and PhD. in Genetics (USP). He is now in the DNA repair Lab as a Post-Doc fellow, with main interests in the: Role of microRNAs in the response to UV-induced stress.

Research abstract

Thirteen years after the discovery of the first “small temporal RNA” (stRNAs), the small RNAs are considered expression modulators of extreme importance, adding a new level of complexity to our understanding about gene expression regulation. There are many recent contributions connecting the silencing machinery with the response to DNA damage. Our goal is to study the influence of miRNA silencing in the response to ultraviolet (UV)-induced damage in fibroblast cell lines. Furthermore, we are also interested in the in silico determination of the mechanisms controlled by miRNAs, with a special interest in miRNAs involved in the control of repair mechanism.

Selected publications

Rassi DM, Junta CM, Fachin AL, Sandrin-Garcia P, Mello SS, Fernandes AP, Deghaide NN, Foss-Freitas MC, Foss MC, Sakamoto-Hojo ET, Passos GA, Donadi EA. Is HLA class II profile relevant for the study of large-scale differentially expressed genes in type 1 diabetes mellitus patients? Ann N Y Acad Sci. 2006 Oct;1079:305-9.

Trevisan GL, Rassi DM, Baiao AM, Sandrin-Garcia P, Mello SS, Tamia-Ferreira MC, Junta CM, Fachin AL, Marques MM, Sakamoto-Hojo ET, Donadi EA, Passos GA. Using cDNA microarrays to identify human CD19(+) B cell gene products (ESTs) originated from systemic lupus erythematosus susceptibility loci. Autoimmun Rev. 2006 May;5(5):319-23. Epub 2006 Jan 6. Review.

Cardoso RS, Junta CM, Macedo C, Magalhaes DA, Silveira EL, Paula MO, Marques MM, Mello SS, Zarate-Blades CR, Nguyen C, Houlgatte R, Donadi EA, Sakamoto-Hojo ET, Passos GA. Hybridization signatures of gamma-irradiated murine fetal thymus organ culture (FTOC) reveal modulation of genes associated with T-cell receptor V(D)J recombination and DNA repair. Mol Immunol. 2006 Feb;43(5):464-72. Epub 2005 Apr 13.

Marques MM, Junta CM, Cardoso RS, Mello SS, Sakamoto-Hojo ET, Donadi EA, Passos GA. Changes in the gene expression profiling of the thymus in response to fibrosarcoma growth. Mol Cell Biochem. 2005 Aug;276(1-2):81-8.

Magalhaes DA, Macedo C, Junta CM, Mello SS, Marques MM, Cardoso RS, Sakamoto-Hojo ET, Donadi EA, Passos GA. Hybridization signatures during thymus ontogeny reveals modulation of genes coding for T-cell signaling proteins. Mol Immunol. 2005 May;42(9):1043-8. Epub 2004 Nov 23.

Pereira E, Tamia-Ferreira MC, Cardoso RS, Mello SS, Sakamoto-Hojo ET, Passos GA, Donadi EA. Immunosuppressive therapy modulates T lymphocyte gene expression in patients with systemic lupus erythematosus. Immunology. 2004 Sep;113(1):99-105.

Sakamoto-Hojo ET, Mello SS, Pereira E, Fachin AL, Cardoso RS, Junta CM, Sandrin-Garcia P, Donadi EA, Passos GA. Gene expression profiles in human cells submitted to genotoxic stress. Mutat Res. 2003 Nov;544(2-3):403-13.

Peitl P*, Mello SS*, Camparoto ML, Passos GA, Hande MP, Cardoso RS, Sakamoto-Hojo ET. Chromosomal rearrangements involving telomeric DNA sequences in Balb/3T3 cells transfected with the Ha-ras oncogene. Mutagenesis. 2002 Jan;17(1):67-72. * : same contribution

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