Stephano Spanó Mello
From DNA Repair Lab
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== Research abstract == | == Research abstract == | ||
- | Thirteen years after the discovery of the first “small temporal RNA” (stRNAs), the small RNAs are considered expression modulators of extreme importance, adding a new level of complexity to our understanding about gene expression regulation. There are many recent contributions connecting the silencing machinery with the response to DNA damage. | + | 1 Thirteen years after the discovery of the first “small temporal RNA” (stRNAs), the small RNAs are considered expression modulators of extreme importance, adding a new level of complexity to our understanding about gene expression regulation. There are many recent contributions connecting the silencing machinery with the response to DNA damage. |
Our goal is to study the influence of miRNA silencing in the response to ultraviolet (UV)-induced damage in fibroblast cell lines. Furthermore, we are also interested in the <i> in silico</i> determination of the mechanisms controlled by miRNAs, with a special interest in miRNAs involved in the control of repair mechanism. | Our goal is to study the influence of miRNA silencing in the response to ultraviolet (UV)-induced damage in fibroblast cell lines. Furthermore, we are also interested in the <i> in silico</i> determination of the mechanisms controlled by miRNAs, with a special interest in miRNAs involved in the control of repair mechanism. | ||
==Selected publications== | ==Selected publications== | ||
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*Peitl P*, Mello SS*, Camparoto ML, Passos GA, Hande MP, Cardoso RS, | *Peitl P*, Mello SS*, Camparoto ML, Passos GA, Hande MP, Cardoso RS, | ||
- | Sakamoto-Hojo ET. | + | Sakamoto-Hojo ET. Chromosomal rearrangements involving telomeric DNA sequences in Balb/3T3 cells |
- | Chromosomal rearrangements involving telomeric DNA sequences in Balb/3T3 cells | + | transfected with the Ha-ras oncogene. Mutagenesis. 2002 Jan;17(1):67-72. |
- | transfected with the Ha-ras oncogene. | + | |
- | Mutagenesis. 2002 Jan;17(1):67-72. | + | |
- | PMID: 11752236 [PubMed - indexed for MEDLINE] | + | |
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