Luciana Nogueira de Sousa Andrade
From DNA Repair Lab
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| == Research project == | == Research project == | ||
| - | Among genetic and biochemical alterations observed in tumors cells, escape from cell death (apoptosis) are responsible in part for drug resistance in malignant neoplasias. | + | Among the genetic and biochemical alterations observed in tumors cells, escape from cell death (apoptosis) are responsible in part for drug resistance in malignant neoplasias. Modification in apoptotic gene expression and drug metabolism are involved in tumor cells sensibility to chemotherapeutic compounds which confers resistance to the killer effect of these drugs. Recently, it has been shown that DNA repair genes are somehow involved in chemorresistance in tumor cells. De fato, o efeito citotóxico da maioria dos quimioterápicos é decorrente de danos na molécula de DNA da célula, de modo que alterações nas vias de reparo dessas lesões pode estar relacionada à aquisição de um fenótipo quimiorresistente por clones celulares malignos. |
Revision as of 00:11, 3 July 2007
Undergraduated in Biology at University of São Paulo. Master degree in Biophysics and Physiology and PhD in Oncology. Nowadays, I am supported by a Postdoctoral Fellowship from FAPESP.
Research project
Among the genetic and biochemical alterations observed in tumors cells, escape from cell death (apoptosis) are responsible in part for drug resistance in malignant neoplasias. Modification in apoptotic gene expression and drug metabolism are involved in tumor cells sensibility to chemotherapeutic compounds which confers resistance to the killer effect of these drugs. Recently, it has been shown that DNA repair genes are somehow involved in chemorresistance in tumor cells. De fato, o efeito citotóxico da maioria dos quimioterápicos é decorrente de danos na molécula de DNA da célula, de modo que alterações nas vias de reparo dessas lesões pode estar relacionada à aquisição de um fenótipo quimiorresistente por clones celulares malignos.