Keronninn Moreno de Lima Bessa
From DNA Repair Lab
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== Publications == | == Publications == | ||
- | 1.[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=18042584&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Armelini MG, '''LIMA-BESSA KM''', Marchetto MC, Muotri AR, Chiganças V, Leite RA, Carvalho H, Menck CF]. Exploring DNA damage responses in human cells with recombinant adenoviral vectors. ''Hum Exp Toxicol'', v. 26, n. 11, p. 899-906, 2007. <br> <br> | + | 1. [http://www.ncbi.nlm.nih.gov/pubmed/18096446?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum '''LIMA-BESSA KM''', Armelini MG, Chiganças V, Jacysyn JF, Amarante-Mendes GP, Sarasin A, Menck CF].CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells. ''DNA Repair'', v. 7, n. 2, p. 303-312, 2008.<br> <br> |
- | 2. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17584035&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Menck, CF, Armelini, MG, '''LIMA-BESSA KM'''].On the search for skin gene therapy strategies of xeroderma pigmentosum disease. ''Current Gene Therapy'', v. 7, n. 3, p. 163-174, 2007. <br> <br> | + | 2. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=18042584&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Armelini MG, '''LIMA-BESSA KM''', Marchetto MC, Muotri AR, Chiganças V, Leite RA, Carvalho H, Menck CF]. Exploring DNA damage responses in human cells with recombinant adenoviral vectors. ''Hum Exp Toxicol'', v. 26, n. 11, p. 899-906, 2007. <br> <br> |
- | 3. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16798111&query_hl=1&itool=pubmed_docsum '''LIMA-BESSA KM''', Chiganças V, Stary A, Kannouche P, Sarasin A, Armelini MG, Jacysyn JF, Amarante-Mendes, GP, Cordeiro-Stone M, Cleaver JE, Menck CF]. Adenovirus mediated transduction of the human DNA polymerase eta cDNA. ''DNA Repair'', v. 5, p. 925-934, 2006. <br> <br> | + | 3. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17584035&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Menck, CF, Armelini, MG, '''LIMA-BESSA KM'''].On the search for skin gene therapy strategies of xeroderma pigmentosum disease. ''Current Gene Therapy'', v. 7, n. 3, p. 163-174, 2007. <br> <br> |
- | 4. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15668158&query_hl=1&itool=pubmed_docsum '''LIMA-BESSA KM''', Menck CF]. Skin cancer: lights on genome lesions. ''Current Biology'', v. 15, p. 58-61, 2005. <br> <br> | + | 4. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16798111&query_hl=1&itool=pubmed_docsum '''LIMA-BESSA KM''', Chiganças V, Stary A, Kannouche P, Sarasin A, Armelini MG, Jacysyn JF, Amarante-Mendes, GP, Cordeiro-Stone M, Cleaver JE, Menck CF]. Adenovirus mediated transduction of the human DNA polymerase eta cDNA. ''DNA Repair'', v. 5, p. 925-934, 2006. <br> <br> |
- | 5. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? | + | 5. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15668158&query_hl=1&itool=pubmed_docsum '''LIMA-BESSA KM''', Menck CF]. Skin cancer: lights on genome lesions. ''Current Biology'', v. 15, p. 58-61, 2005. <br> <br> |
- | db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15650764&query_hl=1&itool=pubmed_docsum Armelini MG, Marchetto MC, Muotri AR, '''LIMA-BESSA KM''', Sarasin A, Menck CF]. Restoring DNA repair capacity of cells from three distinct diseases by XPD gene-recombinant adenovirus. ''Cancer Gene Therapy'', v. 12, p. 389-396, 2005. <br> <br> | + | 6. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15650764&ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Armelini MG, Marchetto MC, Muotri AR, '''LIMA-BESSA KM''', Sarasin A, Menck CF]. Restoring DNA repair capacity of cells from three distinct diseases by XPD gene-recombinant adenovirus. ''Cancer Gene Therapy'', v. 12, p. 389-396, 2005. <br> <br> |
- | 6. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15333143&query_hl=1&itool=pubmed_docsum Martins-Pinheiro M, Galhardo RS, Lage C, '''LIMA-BESSA KM''', Aires KA, Menck CF]. Different patterns of evolution for duplicated DNA repair genes in bacteria of the Xanthomonadales group. ''BMC Evolutionary Biology'', v. 4, p. 1-9, 2004. | + | 7. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15333143&query_hl=1&itool=pubmed_docsum Martins-Pinheiro M, Galhardo RS, Lage C, '''LIMA-BESSA KM''', Aires KA, Menck CF]. Different patterns of evolution for duplicated DNA repair genes in bacteria of the Xanthomonadales group. ''BMC Evolutionary Biology'', v. 4, p. 1-9, 2004. |
Current revision
I undergraduated in Biology at the Federal University of Rio Grande do Norte. In 2006, I got my PhD in Biotechnology at the University of Sao Paulo, Brazil. Nowadays, I am supported by a Postdoctoral Fellowship from FAPESP.
[edit] Research projectUltraviolet light (UV) generates DNA lesions, cyclobutante pyrimidine dimers (CPDs) and 6-4 pyrimidine-pyrimidone photoproducts being the most frequent ones. These DNA lesions can be removed from the genome by two different DNA repair processes: photoreactivation and nucleotide excision repair (NER). Photoreactivation involves enzymes named photolyases, which contain chromophores that capture blue photons and use them to repair the UV photoproducts. Interestingly, these enzymes present a high specificity to the target lesion, being classified as CPD-photolyases and 6-4PP-photolyases. Even though photoreactivation has been found widespread in the nature, these enzymes are absent in placental mammals, including humans. In these organisms, repair of UV-induced DNA lesions is performed by NER. Our research work is interested in investigating the effects of CPDs and 6-4PPs on the induction of cellular responses upon UV irradiation. For this purpose, we have constructed adenoviral vectors carrying the marsupial CPD-photolyase and plant 6-4PP-photolyase. So far, we have been able to demonstrate that both CPDs and 6-4PPs play important roles in cell death pathways in NER-deficient human fibroblasts, while CPDs are the major signals that lead NER-proficient human cells to death. At this time, we have been employing these recombinant adenoviral vectors for studying the effects of CPDs and 6-4PPs in cellular processes such as DNA replication and RNA transcription, which are inhibited by UV irradiation. [edit] Publications1. LIMA-BESSA KM, Armelini MG, Chiganças V, Jacysyn JF, Amarante-Mendes GP, Sarasin A, Menck CF.CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells. DNA Repair, v. 7, n. 2, p. 303-312, 2008. |