Alexandre Teixeira Vessoni
From DNA Repair Lab
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== Research Project == | == Research Project == | ||
- | Autophagy is a lysosomal-dependent degradative pathway that promotes recycling of cytoplasmic components, such as organelles and proteins, aiming at maintaining cellular homeostasis. | + | Autophagy is a lysosome-dependent degradative pathway that promotes recycling of cytoplasmic components, such as organelles and proteins, aiming at maintaining cellular homeostasis. |
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This process can be activated under different stressful situations, such as starvation, oxidative stress and DNA damage. Deficiencies in this pathway were associated to cardiopathies, cancer, neurodegeneration and aging. | This process can be activated under different stressful situations, such as starvation, oxidative stress and DNA damage. Deficiencies in this pathway were associated to cardiopathies, cancer, neurodegeneration and aging. |
Current revision
Graduate in Biological Sciences (University of São Paulo), develops a PhD project entitled "Autophagy Analysis in response to DNA damage" in the Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
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[edit] Research ProjectAutophagy is a lysosome-dependent degradative pathway that promotes recycling of cytoplasmic components, such as organelles and proteins, aiming at maintaining cellular homeostasis.
Autophagosomes in glioma cells (U87MG) stably expressing LC3-GFP (lentiviral transduction) can be analyzed under a fluorescence microscope.
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