Daniela Tathiana Soltys

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I graduated in Biological Sciences at the University of São Paulo in 2003. Presently, I’m a PhD student at the Department of Microbiology at ICB/USP, working on the project Movement of XPG in the cell nucleus exposed to genotoxic agents, and analysis of the genetic nature of Brazilian XP patients.

Research abstract

In order to contribute to the elucidation of the mechanisms involved in DNA repair, specially when the protein XPG is involved, we are determining the mutation present in Brazilian patients diagnosed as XP-G. Also, we are constructing recombinant adenoviruses carrying the cDNA of xpg gene and the egfp reporter gene. This vector will be used in complementation assays with XPG-/- cells. These adenoviruses will be useful to verify the dynamic of this protein in the nucleus of proficient and deficient-DNA repair cells, upon irradiation with UV light or after the exposure to Methylene Blue and light, an agent that induces oxidative lesions. We expect that this work may contribute to better understand the role of the protein XPG against the lesions present in the DNA.

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