Carlos Frederico Martins Menck

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Full Professor at the Dept. of Microbiology, of Institute of Biomedical Sciences, University of São Paulo. Graduated with major in Biology, and PhD in Biochemistry.

Research Project

The main research interests of this group are the study of cellular DNA repair processes and their biological consequences (such as mutagenesis and cell death). The DNA repair lab has developed viral systems related to gene transduction to cells and/or organisms, aiming XP gene therapy, and, recently, this group is using RNAi tools for the understanding the cell responses to genome aggression, in animal cells. Considering the high levels of conservation of DNA repair genes in all living organisms, this group also investigates how these processes occur in plants and in bacteria. These studies also allow an evolutive approach research projects.

Main Publications

01. Menck, CFM (2002) Shining a light on photolyases. Nature Genetics, News and Views, 32: 338-339.(PDF)

02. Costa RM, Chiganças V, Galhardo RS, Carvalho H, Menck CFM (2003) The eukaryotic nucleotide excision repair pathway. Biochimie, 85: 1083-1099.(PDF)

03. Marchetto MCN*, Muotri AR*, Burns DK, Friedberg EC and Menck CFM (2004) Gene transduction in skin cells: preventing cancer in xeroderma pigmentosum mice. Proc. Natl. Acad. Sci. USA 101 (51): 17759-64. Both authors have equally contributed.(PDF)

04. Lima-Bessa KM, Armelini MG, Chiganças V, Jacysyn JF, Amarantes-Mendes GP, Sarasin A and Menck CFM (2008) CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells, DNA Repair 7(2): 303-312.(PDF)

05. Batista LF, Kaina B, Meneghini R, Menck CF (2009) How DNA lesions are turned into powerful killing structures: Insights from UV-induced apoptosis. Mutat Res Reviews, 681(2-3):197-208.(PDF)

06. Lima WC, Varani AM and Menck CF (2009) NAD biosynthesis evolution in bacteria: lateral gene transfer of kynurenine pathway in Xanthomonadales and Flavobacteriales. Molecular Biology of Evolution, 26(2): 399-406.(PDF)

07. Leite, RA, Marchetto, MC, Muotri, AC, Vasconcelos, DM, Oliveira, ZNP, Machado MCR , Menck, CF (2009) Identification of XP complementation groups by recombinant adenovirus carrying DNA repair genes. Journal Investigative Dermatology, 129(2):502-506.(PDF)

08. Batista LF, Roos WP, Kaina B and Menck CF (2009) p53 mutant human glioma cells are sensitive to UV-C induced apoptosis due to impaired CPD removal. Molecular Cancer Research 7(2): 237-246.(PDF)

09. Cutiño-Jiménez AM, Martins-Pinheiro M, Lima WC, Martín-Tornet A, Morales OG, Menck CFM (2010) Evolutionary placement of Xanthomonadales based in conserved protein signature sequences. Molecular Phylogenetics and Evolution, 54: 524-534.(PDF)

10. Schuch AP, Menck CF (2010) The genotoxic effects of DNA lesions induced by artificial UV-radiation and sunlight. J Photochem Photobiol B; 99(3): 111-116.(PDF)

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