Julio Cesar Batista Ferreira


Professor Doutor

Local de Trabalho:

Depto Anatomia -


(011) 3091-0931


(011) 3091-7366


  CV Lattes:  

 Análise integrada de sinais biológicos envolvidos na regulação bioenergética e controle de qualidade celular em doenças degenerativas.




The main focus of our lab is to understand the role of cytosolic and mitochondrial quality control in cardiovascular diseases such as cardiac ischemia, heart failure and hypertension. We are currently interested in understanding how ubiquitin-proteasome system disruption interacts/affects mitochondrial dynamics and bioenergetics. Another issue we are working on is how aldehydic load disrupts mitochondrial metabolism and cellular contractility in cardiovascular and skeletal muscle diseases.

Our lab have used both pharmacological (peptides rationally designed targeting intracellular protein-protein interactions) and non-pharmacological tools (exercise training) to better understand the physiology, biochemistry and biology of degenerative diseases.






 - Ferreira JCB, Boer BN, Grinberg M, Brum PC, Mochly-Rosen D. Protein quality control disruption by PKCbII; rescue by the selective PKCbII inhibitor, bIIV5-3. PLoS One, v.7, p. e33175, 2012.

 - Sun L, Ferreira JCB, Mochly-Rosen D. ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance. Science Translational Medicine, v2, p. 107-11, 2011.

 - Ferreira JCB, Koyanagi T, Palaniyandi SS, Fajardo G, Churchill EN, Budas G, Disatnik MH, Bernstein D, Brum PC, Mochly-Rosen D. Pharmacological inhibition of bIIPKC is cardioprotective in late-stage hypertrophy. Journal of Molecular and Cellular Cardiology, v51, p. 980-7, 2011.

 - Ferreira JCB, Palaniyandi SS, Brum PC, Mochly-Rosen D. PKCbetaII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responsesJournal of Cellular and Molecular Medicine, v15, p. 1769-77, 2011.

 - Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D. Ischaemic preconditioning improves proteasomal activity and increases the degradation of PKC during reperfusion. Cardiovascular Research, v. 85, p. 385-394, 2010.

 - Palaniyandi SS, Sun L, Ferreira JCB, Mochly-Rosen D. Protein kinase C in heart failure: a therapeutic target?. Cardiovascular Research, v. 82, p. 229-239, 2009.

 - Oliveira RSF, Ferreira JCB, Gomes ERM, Paixao NP, Rolim NPL, Medeiros A, Guatimosim S, Brum PC. cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice. Journal of Physiology (London), v. 587, p. 3899-3910, 2009.

 - Bartholomeu J, Vanzelli A, Rolim N, Ferreira JCB, Bechara L, Tanaka L, Rosa K, Alves M, Medeiros A, Mattos K, Coelho MA, Irigoyen MC, Krieger EM, Krieger JE, Negrao CE, Ramires PR, Guatimosim S, Brum PC. Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure. Journal of Molecular and Cellular Cardiology, v. 45, p. 240-249, 2008.

 - Ferreira JCB, Rolim NPL, Bartholomeu JB, Gobatto CA, Kokubun E, Brum PC. Maximal lactate steady state in running mice: effect of exercise training. Clinical and Experimental Pharmacology & Physiology, v. 34, p. 760-765, 2007.

 - Ferreira JCB, Bacurau AV, Evangelista FS, Coelho MA, Oliveira EM, Casarini DE, Krieger JE, Brum PC. The role of local and systemic renin angiotensin system activation in a genetic model of sympathetic hyperactivity-induced heart failure in mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, v. 294, p. R26-R32, 2007.


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Última Atualização 13/09/2012