DOCENTE

 

Julio Cesar Batista Ferreira


Título: Professor Doutor

 

Telefone: (011) 3091-0931
Fax: (011) 3091-7366
E-mail: JLIB_HTML_CLOAKING

Site: 

 

Linha de Pesquisa

Análise integrada de sinais biológicos envolvidos na regulação bioenergética e controle de qualidade celular em doenças degenerativas.

 

Descrição

The paradigm of mitochondrial biology has been dramatically changed over the last years. Besides their ability in generating ATP, mitochondria have been recently classified as key intracellular sensors, integrators and effectors; therefore playing a critical role in cellular homeostasis. Our lab has been working during the last years in deciphering the mitochondrial “node” function as well as its contribution to cellular biology. The main focus of our lab is to understand the role of mitochondria in integrating intracellular signals that affect function, morphology and life/death decisions of somatic cells (especially those long-lived differentiated cells such as cardiac myocytes) under health and disease conditions. We use different molecular, biochemical and physiological approaches to discover and validate new mitochondrial-related targets that affect cardiac biology. We also generate/screen new molecules capable of modulating mitochondrial “node” function with further application in therapeutics. Our lab has already worked on three molecules that affect mitochondrial “node” function, which might be used in the future to treat cardiac ischemia injury and heart failure (ongoing studies). Finally, our lab is currently interested in better understanding how mitochondrial quality control mechanisms (including mitochondrial retrograde signaling, aldehydic metabolism, protein turnover, dynamics and clearance) affect the biology of cardiac cells (including cardiac myocytes, fibroblast and mast cells) as well as progenitor cell fate decisions (stemness-and-differentiation decision). These studies will help us to develop more powerful and selective molecules to treat cardiac diseases.

 

Principais Trabalhos Publicados

  • Ferreira JCB, Boer BN, Grinberg M, Brum PC, Mochly-Rosen D. Protein quality control disruption by PKCbII; rescue by the selective PKCbII inhibitor, bIIV5-3. PLoS One, v.7, p. e33175, 2012.
  • Sun L, Ferreira JCB, Mochly-Rosen D. ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance. Science Translational Medicine, v2, p. 107-11, 2011.
  • Ferreira JCB, Koyanagi T, Palaniyandi SS, Fajardo G, Churchill EN, Budas G, Disatnik MH, Bernstein D, Brum PC, Mochly-Rosen D. Pharmacological inhibition of bIIPKC is cardioprotective in late-stage hypertrophy. Journal of Molecular and Cellular Cardiology, v51, p. 980-7, 2011.
  • Ferreira JCB, Palaniyandi SS, Brum PC, Mochly-Rosen D. PKCbetaII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses. Journal of Cellular and Molecular Medicine, v15, p. 1769-77, 2011.
  • Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D. Ischaemic preconditioning improves proteasomal activity and increases the degradation of PKC during reperfusion. Cardiovascular Research, v. 85, p. 385-394, 2010.
  • Palaniyandi SS, Sun L, Ferreira JCB, Mochly-Rosen D. Protein kinase C in heart failure: a therapeutic target?. Cardiovascular Research, v. 82, p. 229-239, 2009.
  • Oliveira RSF, Ferreira JCB, Gomes ERM, Paixao NP, Rolim NPL, Medeiros A, Guatimosim S, Brum PC. cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice. Journal of Physiology (London), v. 587, p. 3899-3910, 2009.
  • Bartholomeu J, Vanzelli A, Rolim N, Ferreira JCB, Bechara L, Tanaka L, Rosa K, Alves M, Medeiros A, Mattos K, Coelho MA, Irigoyen MC, Krieger EM, Krieger JE, Negrao CE, Ramires PR, Guatimosim S, Brum PC. Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure. Journal of Molecular and Cellular Cardiology, v. 45, p. 240-249, 2008.
  • Ferreira JCB, Rolim NPL, Bartholomeu JB, Gobatto CA, Kokubun E, Brum PC. Maximal lactate steady state in running mice: effect of exercise training. Clinical and Experimental Pharmacology & Physiology, v. 34, p. 760-765, 2007.
  • Ferreira JCB, Bacurau AV, Evangelista FS, Coelho MA, Oliveira EM, Casarini DE, Krieger JE, Brum PC. The role of local and systemic renin angiotensin system activation in a genetic model of sympathetic hyperactivity-induced heart failure in mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, v. 294, p. R26-R32, 2007.